Idizayini yempahla eluhlaza entsha

Ukuzihlanganisa kwamangqamuzana

--ikhemistri eluhlaza ngaphandle kokuphulwa kwebhondi nokuxhuma kabusha

Umgomo oyinhloko wokuzihlanganisa kwamangqamuzana:

1. Njengokuheha njengokufana - ukushayela izinto ezifanayo ukuze ziqoqe futhi zihlele zodwa, kanye nezinto ezinezici ezihambisanayo ukuze zihehe.

2. Amandla aphansi kakhulu—ukunyakaza kwezindaba kanye nokuziphatha kwamangqamuzana kuzothambekela esimeni esizinzile. Kuyindlela yokuthi amaqembu amangqamuzana ahlelwe abe izakhiwo ezithuthukile.

Ukwakheka kwama-molecular self-assembly, ukwakheka kwe-CP phakathi kwama-molecule kungathuthukisa kakhulu umsebenzi webhayoloji:

1. I-molecule ngayinye inesakhiwo sayo esiyingqayizivele kanye nezici zokusebenza, futhi kunzima ukufeza i-synergy kanye nokwelashwa okunembile okusekelwe ekuxubeni kwamahhala ezingeni lokubunjwa.

2. Kusenama-molecule amaningi anomsebenzi omuhle kakhulu webhayoloji anciphise kakhulu ukumuncwa kwawo nokusetshenziswa kwawo ngenxa yezimpawu zawo ezingezinhle.

3. Izinto ezisebenzayo zomuthi wendabuko waseShayina zibaluleke kakhulu mayelana "nenkosi, izikhonzi kanye nabasizi", kunokuba i-hodgepodge engcono kakhulu.

Ukuguqulwa kwesakhiwo se-Supramolecular kanye nemodeli yenqubo yokuhlaziya yokuthuthukisa:

1. Ukuhlolwa kokusebenza okuphezulu okusizwa ngekhompyutha ukuze kuhlolwe ngokushesha izandulela ezifanele ezivela e-Cambridge Crystal Data Center.

2. Sebenzisa ithiyori yokusebenza kokuminyana ukuze ufunde isakhiwo se-supramolecular nezici zokuhlanganisa ezinqunywa amandla e-intermolecular, futhi unqume ukuthi yiluphi uhlobo lwe-supramolecular oluwumkhuba wokwakheka.

3. Ngokuhlaziya izimo zokusabela nobunzima, isakhiwo se-supramolecular sathuthukiswa.

4. Ukubalwa kwezakhiwo ezihlukahlukene zama-supramolecules, okuhlanganisa izakhiwo zikagesi, ezibonakalayo kanye ne-thermodynamic.

5. Ukubalwa kwezakhiwo ze-spectral ezifana ne-molecular spectrum kanye ne-energy spectrum.

6.Ngobuchwepheshe be-molecular docking, amasayithi okusebenzelana phakathi kwezinto ezingavuthiwe ze-supramolecular kanye namaprotheni okuhlosiwe ayabikezelwa, futhi indlela yokusebenzisana phakathi kwama-molecule ichazwa ngokujulile.

Ubuchwepheshe be-Supramolecular eutectic/Ionic salt

Izici zobuchwepheshe: okokuqala embonini, ukuhlola izingxenye ze-CP ezihamba phambili zezingxenye ezisebenzayo zokuqinisa i-eutectic

Izinzuzo: ukunciphisa ukucasuka, ukuthuthukisa ukunyibilika, ukuthuthukisa ukusebenza, ukuthuthukisa ukungena, ukuthuthukisa ukuzinza

Izibonelo zezithako: i-salicylic acid, i-uric acid, i-ferulic acid, i-glycyrrhizic acid, i-adenosine, i-niacinamide, i-4MSK

Izithako ezisebenzayo zemvelo ezithathwe kukhathalogi yezinto zokusetshenziswa zezimonyo, ngemuva kokuhlolwa kokuqinisekisa okufana nokulingiswa kwamakhemikhali e-quantum, ukuhlolwa komphumela ophezulu, ukwenziwa ngcono kwe-Gaussian, i-KingDraw, i-MestReNova, i-FTIR, ne-NMR, imikhiqizo etholiwe inokwakheka okuhle kakhulu kwekristalu enezinhlangothi ezintathu, ukuzinza okuhle, ukuhlanzeka okuphezulu, ukungcola okuncane. Ingakwazi ukuxazulula ngokuphumelelayo amaphuzu obuhlungu ohlelo lokusebenza lwezithako ezisebenzayo ekudleni, imithi nezimonyo, futhi ithuthukise i-bioavailability nokuphepha kwezithako ezisebenzayo.

Ubuchwepheshe bokukhipha umsebenzi we-Supramolecular

izici ze-echnical: Eyokuqala yemboni, inhlanganisela yobuchwepheshe bokuphrinta be-molecular kanye nezinyibilikitsi zemvelo ze-supramolecular, ukukhishwa okusebenzayo kwezithako ezisebenzayo zezitshalo

Izinzuzo: Ukukhishwa okuhlosiwe, ukusebenza kahle kokukhipha kukhuphuka izikhathi ezi-5 uma kuqhathaniswa nokukhipha utshwala, futhi ukuchithwa kwamanzi kukhuphuka izikhathi ezingu-20; akukho ukuhlukaniswa, ukuncishiswa kwezindleko, izithako ezikhuthaza ukungena Izibonelo: i-olive (oleuropein, i-hydroxytyrosol), i-rhodiola, i-Phyloporus yokwelapha, i-white water lily, i-micrococcus

Natural deep eutectic solvent (NaDES): Yaqala ukutholwa ososayensi ekuhlaziyeni i-metabolomics yezitshalo. Phakathi nezigaba ezithile zokukhula zezitshalo (ukuhluma, ukucryopreservation), amaseli azozenzela ngokuzenzakalelayo uketshezi olubonayo oluzimele ngaphandle kwamanzi nama-lipids, olufana nengxube ye-eutectics.

Ngokusekelwe kubuchwepheshe besimanje bokuhlukanisa okuluhlaza, ubuchwepheshe obuhlanganisiwe be-membrane, obuhambisana nobuchwepheshe bokuthuthukisa i-ultrasonic / microwave ukuze kuzuzwe izinga lokushisa eliphansi, elihlosiwe, i-ciency ephezulu, ikhwalithi ephezulu kanye nokukhishwa okuluhlaza kwezingxenye ezisebenzayo.Nge-solvent yemvelo ye-supramolecular njenge-solvent esebenza kahle yokukhipha, ixazulula izinkinga eziningi ezifana nokusebenza kahle okuphansi, izindleko eziphezulu kanye nobunzima ekukhishweni koketshezi lwe-phytochemical okukhethiwe okukhethiwe. I-solvent ye-supramolecular ekhethiwe inokusebenza okuzinzile kanye nokuncibilika okuthuthukisiwe kwezithako ezisebenzayo, futhi ukusebenza kahle kokukhipha kungakhuphuka izikhathi ezingama-20.

Ubuchwepheshe bokungena kwe-Supramolecular synergistic

Izici zobuchwepheshe: Eyokuqala yemboni, ngokusebenzisa i-supramolecular solvent synergistically ikhuthaza ukungena kwama-macromolecules/amanzi-ancibilikayo/okunzima ukumunca izithako.

Izinzuzo zezobuchwepheshe: ukuqina okuthuthukisiwe, ukuthuthukiswa kokungena okungabhubhisi nokusebenza kahle, umphumela we-synergistic, ukucebisa okuqondisayo ku-dermis, kanye ne-bioavailability yanda izikhathi ezingu-5-7 Izithako izibonelo: i-collagen, i-Bosein, i-peptide yethusi eluhlaza okwesibhakabhaka, i-hexapeptide, i-peptide ehlanganisiwe, i-β-glucan.

Njengoba isisindo samangqamuzana e-peptide sisesikhulu uma siqhathaniswa nezinye izithako ezisebenzayo, ukungena kwesikhumba kuphansi. Ezinye izindlela zokuthuthukisa ukungena ziyadingeka ukuze kuthuthukiswe umphumela wokumunca othuthukisa ukungena kwe-peptide, ukuze kuzuzwe ukugxilisa ingqondo okuphansi nokusebenza kahle okuphezulu, futhi kuzuzwe ukusebenza kahle okunqanda ukuguga.

Ukusabela embonini yephuzu elibuhlungu lokungena kahle, i-hydrophilicity ephezulu kanye ne-bioavailability ephansi yama-macromolecules endabuko, i-JUNAS Time Particle products synthesis nge-quantum chemistry esizwa, ingafinyelela ngokuqondile ku-epidermis kanye ne-dermis yesikhumba ngokusebenzisa i-trans-cellular, intercellular kanye ne-follicular sweat ductchannels. Ngaphandle kokulimaza isakhiwo sesikhumba.I-bioavailability yomkhiqizo ikhuphuka izikhathi ezingu-5, kufaka phakathi okungaphezulu kuka-45% ku-dermis, ngaphandle kokulimaza isakhiwo sesikhumba.Umphumela wokungena kanye nesikhathi sokuhlala kufinyelelwe ukuthuthukiswa okuphawulekayo.Lesi yisona sokuqala sohlobo lwayo embonini.

Ubuchwepheshe be-supramolecular biocatalysis

I-catalysis eqondiswe ku-Bioenzyme: izinyibilikisi ze-supramolecular zisetshenziswa njengama-substrates ukuthuthukisa umsebenzi we-enzyme, ukuthuthukisa ukukhethwa kwe-chiral, futhi kufinyelele ubumsulwa obukhulu.

Ubunjiniyela be-fennel green fermentation: khetha izitshalo eziyisici, uthuthukise okuqukethwe kwezithako ezisebenzayo, ifomula ye-anhydrous, uthuthukise ukusebenza kahle okuphelele.

I-reverse micellar fermentation technology: ukuhlola uhlobo lwesici, uwoyela wemifino ovubelayo, imiphumela eyengeziwe, ukuthuthukisa ukuzwakala kwesikhumba nokuthuthukisa ukumuncwa.

Ngokusekelwe kubuchwepheshe bezakhi zofuzo ezihlanganisiwe, ubuchwepheshe be-cloning yesinyathelo esisodwa kanye nobuchwepheshe be-high-density bioenzyme catalytic, amagciwane akhiwe ngofuzo asetshenziswa njengabathwali be-catalytic ukuze babone ukukhiqizwa okukhulu kwezinto ezisebenzayo:

Ngaphansi kwesistimu ye-solvent ye-supramolecular, i-enzyme ikhombisa umsebenzi ophezulu, ukukhetha nokuzinza, ukusetshenziswa okuphezulu kwezinto ezingavuthiwe ze-substrate, ukungcola okuncane ohlelweni lokukhiqiza, izimo zokusabela okuncane, ukusebenza okuphezulu kokuphepha nokusebenza kokukhiqiza.

Buyisela emuva ubuchwepheshe be-micelle fermentation:

amafutha emvelo akhethiwe anezici zesiShayina i-lP aklanywe ngokuzenzakalelayo ukukhiqiza ama-surfactants ngaphansi kwesenzo sebhaktheriya enziwe ngofuzo.lt ihlanganiswa njengomthwali we-anti-micellar bundle ukuze kubonakale ukugoqwa kwenqwaba ye-micellar yezithako ezisebenzayo ezincibilika emanzini ukuze kuzuzwe izimo zohlelo lokusebenza olucebile, isipiliyoni sokugcina sesikhumba, kanye nolwazi oluphawulekayo, ukusebenza kahle okuphawulekayo, ukusebenza kahle okuphawulekayo.

Ubuchwepheshe be-Supramolecular microencapsulation

Izici zobuchwepheshe: i-liposome encapsulation, ukukhululwa okuhlosiwe kwamaseli esikhumba, ukukhululwa okuhlosiwe kwezinwele zezinwele, nokukhululwa okuphendulayo kwezinto ezivuthayo.

Izinzuzo: I-Nanoization, ukulethwa okunembile, ukukhululwa okuhlala isikhathi eside, ukunciphisa ukucasuka, ukuthuthukisa ukuzinza, nokukhuthaza ukungena

Izibonelo zezithako: i-astaxanthin, i-glabridin, ivithamini A, i-peptide yethusi eluhlaza okwesibhakabhaka, i-biotin, i-ceramide, amafutha abalulekile ezitshalo

Ubuchwepheshe be-Supramolecular microencapsulation busekelwe ku-liposome, i-emulsion yamafutha, ubuchwepheshe be-ionic liquid stabilization, i-dermal cell targeted release technology, i-hair follicle ehlosiwe yokukhululwa kobuchwepheshe, kanye nobuchwepheshe bokukhululwa kwesici esivuthayo.Ngokudala iziteshi zokuthutha zokwenziwa, umkhiqizo ungaletha izithako ezisebenzayo ngokunembile. Inezinga elihle kakhulu lokumuncwa kwe-transdermal, isikhathi sokuhlala isikhathi eside kanye nokuzinza okuhle endaweni okuqondiswe kuyo isikhumba. Ibuye ibe nezindleko eziphansi kanye nezicelo ezisebenza kahle kakhulu emkhakheni wezimonyo, ukudla okusebenzayo kanye nemithi.

Ubuchwepheshe bokuzihlanganisa be-Peptide hierarchical

Izici zobuchwepheshe: umthetho wokuqala wemboni, ohlosiwe wesakhiwo sezinga eliphezulu lamaketanga e-amino acid nama-polypeptides, ama-peptide amafushane azihlanganisele wona, ama-polypeptides e-supramolecular

Isiqondiso sobuchwepheshe: Thuthukisa i-amphiphilicity, uthuthukise ukuzinza nokumelana nokushisa, unciphise ubuthi kanye nengcindezi yokuzivikela komzimba, ukhuthaze ukumuncwa, futhi uhlanganise

Izibonelo zezithako: i-supramolecular carnosine, i-yeast protein peptide

Ukuzihlanganisa kwamaprotheni nama-peptide akukhona nje kuphela ukuthi kutholakala yonke indawo ezinhlelweni zokuphila, kodwa futhi kuyindlela enhle kakhulu engapheli yomzimba womuntu, futhi kungenye yezindlela ezisebenzayo zokuhlanganisa izinto ze-nano-biological. Inqubo yokuzihlanganisa ye-peptide iyinqubo yokuhlanganisa elandelanayo, futhi "isakhiwo seziphu ye-amino acid e-polar" siwuhlobo olusha lwesakhiwo se-super-secondary, olusiza ekuhlanganiseni kwe-hierarchical yama-peptide ukuze akhe ama-aggregate a-oda.

Ukulawulwa kokuqondisa kosayizi wama-peptide amafushane kungafinyelelwa ngokushintsha i-hydrophobicity kanye ne-side chain branching yezinsalela ze-hydrophobic.

Ngokusekelwe kudathabheyisi eyingqayizivele ye-Shinehigh Innovation ye-ProteinDataBank (PDB), ihlanganisa nokubheka kokuhlola okuhlelekile, amandla e-molecular dynamics kanye nezibalo zamakhemikhali e-quantum ukuze kuhlaziywe ukwakheka kwama-molecule e-peptide, bese iwafanisa nama-molecule azihlanganisayo aphezulu. ngaleyo ndlela ithuthukise ikhono le-molecule lokuzihlanganisa ngokwalo.Qaphela ukulawulwa okuhlosiwe kwama-peptide. I-peptide ezihlangene ine-amphiphilicity enhle kakhulu kanye ne-symmetry, okuthuthukisa kakhulu ukuzinza kwe-peptide, ikhono le-transdermal kanye ne-bioavailability.