Kwembula isayensi kanye nokusimama ngemuva kwezithako zethu ze-DNA ezithathwe ku-salmon kanye nezitshalo
Selokhu yavunywa okokuqala e-Italy ngo-2008 ukuze ilungiswe izicubu, i-PDRN (polydeoxyribonucleotide) isiphenduke isithako esisezingeni eliphezulu sokuvuselela isikhumba kokubili emikhakheni yezokwelapha neyezimonyo, ngenxa yemiphumela yayo emangalisayo yokuvuselela kanye nephrofayili yokuphepha. Namuhla, isetshenziswa kabanzi emikhiqizweni yezimonyo, izixazululo zobuhle bezokwelapha, kanye nezindlela zokunakekelwa kwesikhumba zansuku zonke.
I-PromaCare PDRNUchungechunge lusebenzisa amandla e-DNA sodium — isithako sesizukulwane esilandelayo esisekelwa yisayensi futhi sithembekile kokubili emitholampilo yesikhumba kanye nokusungula izinto ezintsha. Kusukela ekulungisweni kwesikhumba kuya ekunciphiseni ukuvuvukala, uhla lwethu lwe-PDRN luvuselela ikhono lemvelo lesikhumba lokuphulukisa nokuvuselela. Njengoba sithola imithombo yasolwandle neyezitshalo, sinikeza izinketho ezisebenzayo, eziphephile, neziguquguqukayo ukuze zivumelane nezidingo zanamuhla zokwakheka.
I-Salmon-EtholakalaI-PromaCare PDRN: Ukusebenza Okuqinisekisiwe Ekubuyiseleni Isikhumba
Kukhishwe esidoda se-salmon,I-PromaCare PDRNihlanzwa nge-ultrafiltration, ukugaya i-enzyme, kanye ne-chromatography ukuze ifinyelele ukufana okungaphezu kuka-98% ne-DNA yomuntu. Ivuselela i-adenosine A₂A receptor ukuze iqalise uchungechunge lwezimpawu zokulungisa amaseli. Le ndlela ikhulisa ukukhiqizwa kwe-epidermal growth factor (EGF), i-fibroblast growth factor (FGF), kanye ne-vascular endothelial growth factor (VEGF), ezisiza ekuvuseleleni isikhumba esonakele, zikhuthaze ukuvuselelwa kwe-collagen kanye ne-elastin, futhi zikhuthaze ukwakheka kwama-capillary ukuze kuthuthukiswe ukugeleza kwezakhamzimba.
Ngaphezu kokuthuthukisa ukuthungwa kwesikhumba kanye nokuqina kwaso,I-PromaCare PDRNfuthi kunciphisa ukuvuvukala kanye nomonakalo we-oxidative obangelwa imisebe ye-UV. Kusiza ukulungisa isikhumba esivame ukuba nama-acne kanye nokuzwela, kuthuthukisa ukufiphala, futhi kusekela ukwakhiwa kabusha kwesithiyo sesikhumba ngaphakathi.
Ukusungula Izinto Ezisekelwe Ezitshalweni: I-LD-PDRN kanye ne-PO-PDRN Yokusebenza Kahle Kokuqaphela Imvelo
Kumabhrendi afuna izinketho ezihlanzekile nezisimeme ngaphandle kokubeka engcupheni ukusebenza, i-Uniproma inikeza ama-PDRN amabili asuselwa ezitshalweni:
I-PromaCare LD-PDRN (i-Laminaria Digitata Extract; i-Sodium DNA)
Njengoba ikhishwe ku-algae ensundu (i-Laminaria japonica), lesi sithako sinikeza izinzuzo zesikhumba ezinezingqimba eziningi. Sikhuthaza ukuvuselelwa kwesikhumba ngokuthuthukisa umsebenzi we-fibroblast nokukhuthaza ukukhiqizwa kwe-EGF, FGF, kanye ne-IGF. Siphinde sandise amazinga e-VEGF ukusekela ukwakheka kwama-capillary amasha.
Isakhiwo sayo se-alginate oligosaccharide ensundu siqinisa ama-emulsion, sivimbela ukuvuvukala ngokuvimbela ukufuduka kwama-leukocyte nge-selectin, futhi sicindezela i-apoptosis ngokulawula umsebenzi we-Bcl-2, i-Bax, kanye ne-caspase-3. Isakhiwo se-polymer sesithako sivumela amandla amahle okugcina amanzi, ukuthobisa, kanye nokwenza ifilimu - afanele ukulungisa isikhumba esonakele, esiphelelwe amanzi emzimbeni, noma esicasukile.
I-PromaCare PO-PDRN (i-Platycladus Orientalis Leaf Extract; i-Sodium DNA)
Le PDRN esekelwe ezitshalweni itholakala ku-Platycladus Orientalis futhi inikeza imiphumela yokulwa namagciwane, ukuvuvukala, kanye nokuthambisa. Amafutha aguquguqukayo kanye nama-flavonoid akulesi sithako aphazamisa ulwelwesi lwamagciwane futhi avimbele ukwakheka kwe-nucleic acid, kuyilapho ama-anti-inflammatory agents ecindezela indlela ye-NF-κB ukuze kuncishiswe ukubomvu nokucasuka.
Ama-polysaccharide ayo afumisayo akha ungqimba olubopha amanzi esikhumbeni, oluvuselela ukwakheka kwezinto zemvelo ezifumisayo futhi luqinise umgoqo. Iphinde isekele ukukhiqizwa kwe-collagen futhi iqinise ama-pores - okufaka isandla esikhumbeni esibushelelezi nesinwebekayo.
Zombili i-PDRN zezitshalo zikhishwa ngqo kumaseli ezitshalo kusetshenziswa inqubo eqinile yokuhlanza, enikeza ukuzinza okuphezulu, ukuphepha, kanye nesisombululo esihlanzekile sokunakekelwa kwesikhumba okusebenzayo kakhulu.
Okuqhutshwa Yisayensi, Okugxile Esikhathini Esizayo
Imiphumela ye-in vitro ikhombisa ukuthi u-0.01% we-PDRN ukhulisa ukwanda kwe-fibroblast emazingeni afana no-25 ng/mL we-EGF. Ngaphezu kwalokho, u-0.08% we-PDRN ukhulisa kakhulu ukwakheka kwe-collagen, ikakhulukazi uma kucutshungulwa kube isisindo esiphansi sama-molecule.
Kungakhathaliseki ukuthi ulungiselela ukulungiswa kwezithiyo, ukuvimbela ukuguga, noma ukunakekelwa kokuvuvukala, i-Uniproma'sI-PromaCare PDRNububanzi bunikeza izinketho ezinamandla ezisekelwa izindlela ezicacile kanye nokuthola okuguquguqukayo.
I-salmon noma isitshalo — ukukhetha kungokwakho. Imiphumela ingokoqobo.
Isikhathi sokuthunyelwe: Juni-10-2025