Ukwembula isayensi nokusimama ngemuva kwezithako zethu ze-DNA ezitholakala ku-salmon- kanye nezitshalo
Kusukela yavunywa okokuqala e-Italy ngo-2008 ukuze kulungiswe izicubu, i-PDRN (i-polydeoxyribonucleotide) isiguquke yaba isithako esisezingeni legolide sokuvuselelwa kabusha kwesikhumba kuzo zombili izinkambu zezokwelapha nezimonyo, ngenxa yemiphumela yayo emangalisayo yokuvuselela kanye nephrofayili yokuphepha. Namuhla, isetshenziswa kakhulu emikhiqizweni yezimonyo, izixazululo zobuhle bezokwelapha, kanye nokwakhiwa kwesikhumba kwansuku zonke.
Inkampani PromaCare PDRNuchungechunge lusebenzisa amandla e-DNA sodium - isithako sesizukulwane esilandelayo esisekelwa isayensi futhi esithenjwa kuyo yomibili imitholampilo yesikhumba kanye nokuqamba okusha kwezimonyo. Ukusuka ekulungiseni isikhumba kuya ekwehliseni ukuvuvukala, i-PDRN yethu ehlukahlukene yenza kusebenze ikhono lemvelo lesikhumba lokuphola kanye nokwenza kabusha. Ngayo yomibili imithombo yasolwandle neyebhotani etholakalayo, sinikeza izinketho eziphumelelayo, eziphephile, neziguquguqukayo ukuze zifane nezidingo zesimanje zokuklama.
I-Salmon-DerivedInkampani PromaCare PDRN: Ukusebenza Okuqinisekisiwe Ekubuyiseleni Isikhumba
Ikhishwe ku-salmon sperm,Inkampani PromaCare PDRNihlanzwa nge-ultrafiltration, i-enzymatic digestion, kanye ne-chromatography ukuze ifinyelele ukufana okungaphezu kwama-98% ku-DNA yomuntu. Ivula i-adenosine A₂A receptor ukuze iqalise uchungechunge lwamasiginali okulungisa amaselula. Lo mshini uthuthukisa ukukhiqizwa kwe-epidermal growth factor (EGF), i-fibroblast growth factor (FGF), kanye ne-vascular endothelial growth factor (VEGF), esiza ukulungisa kabusha isikhumba esonakele, kukhuthaze ukuvuselelwa kwe-collagen ne-elastin, futhi kukhuthaze ukwakheka kwe-capillary ukuze kuthuthukiswe ukugeleza kwezakhi.
Ngaphezu kokuthuthukisa ukuthungwa nokuqina kwesikhumba,Inkampani PromaCare PDRNfuthi kunciphisa ukuvuvukala kanye nomonakalo oxidative obangelwa imisebe ye-UV. Isiza ukulungisa izinduna kanye nesikhumba esizwelayo, ithuthukise ubuthuntu, futhi isekele ukwakhiwa kabusha komgoqo wesikhumba ngaphakathi.
Ukuqamba Okusekelwe Esitshalweni: I-LD-PDN kanye ne-PO-PDRN Yokusebenza Kwe-Eco-Conscious
Ngemikhiqizo efuna ukuhlanza, izinketho ezisimeme ngaphandle kokuyekethisa ukusebenza, i-Uniproma inikeza ama-PDRN amabili athathwe esitshalweni:
I-PromaCare LD-PDRN (I-Laminaria Digitata Extract; I-Sodium DNA)
Ikhishwe kulwelwe olunsundu (Laminaria japonica), lesi sithako siletha izinzuzo zesikhumba ezinezendlalelo eziningi. Ikhuthaza ukuvuselelwa kwesikhumba ngokuthuthukisa umsebenzi we-fibroblast futhi ikhuthaze ukugcinwa kwe-EGF, FGF, ne-IGF. Iphinde ikhulise amazinga e-VEGF ukusekela ukwakheka kwe-capillary entsha.
Isakhiwo sayo esinsundu se-oligosaccharide siqinisa ama-emulsion, sivimbela ukuvuvukala ngokuvimbela ukufuduka kwe-leukocyte ngama-selectins, futhi sicindezela i-apoptosis ngokulawula umsebenzi we-Bcl-2, Bax, kanye ne-caspase-3. Isakhiwo se-polymer yesithako sivumela ukugcinwa kwamanzi okuhle kakhulu, ukududuza, namandla okwenza ifilimu - alungele ukulungisa isikhumba esonakele, esiphelelwe amanzi, noma esithukuthele.
I-PromaCare PO-PDRN (i-Platycladus Orietalis Leaf Extract; i-Sodium DNA)
Le PDRN esekelwe esitshalweni itholakala ku-Platycladus Orietalis futhi inikeza imiphumela elwa namagciwane, elwa nokuvuvukala, neyomswakama. Amafutha aguquguqukayo nama-flavonoid ekukhishweni aphazamisa ulwelwesi lwebhaktheriya futhi avimbele i-nucleic acid synthesis, kuyilapho ama-anti-inflammatory agents acindezela indlela ye-NF-κB yokunciphisa ubomvu nokucasuka.
Ama-polysaccharides ayo afaka amanzi enza ungqimba olubopha amanzi esikhumbeni, okuvuselela ukwakheka kwezinto ezithambisayo zemvelo nokuqinisa umgoqo. Iphinde isekele ukukhiqizwa kwe-collagen futhi iqinise izimbotshana - okunikela esikhumbeni esibushelelezi, esinwebekayo.
Womabili ama-PDRN ezitshalo akhishwa ngokuqondile kumaseli ezitshalo kusetshenziswa inqubo eqinile yokuhlanza, enikeza ukuzinza okuphezulu, ukuphepha, nesixazululo esinelebula elihlanzekile lokunakekelwa kwesikhumba okusebenza kahle kakhulu.
Iqhutshwa Isayensi, Igxile Ikusasa
Imiphumela ye-in vitro ibonisa u-0.01% we-PDRN ukhulisa ukwanda kwe-fibroblast kumazinga aqhathaniswa no-25 ng/mL we-EGF. Ngaphezu kwalokho, i-0.08% PDRN ikwandisa kakhulu ukuhlanganiswa kwe-collagen, ikakhulukazi uma icutshungulwa kusisindo esiphansi samangqamuzana.
Kungakhathaliseki ukuthi ulungiselela ukulungisa izithiyo, ukulwa nokuguga, noma ukunakekelwa kokuvuvukala, i-Uniproma'sInkampani PromaCare PDRNububanzi bunikeza izinketho ezinamandla ezisekelwa izindlela ezicacile kanye nokutholakala okuguquguqukayo.
I-Salmon- noma i-plant-based - ukukhetha kungokwakho. Imiphumela ingokoqobo.
Isikhathi sokuthumela: Jun-10-2025