I-PromaCare®I-R-PDRN imele intuthuko enkulu ezithakweni zezimonyo ezisekelwe ku-nucleic acid, enikeza i-saumoni ehlanganisiwe ye-PDRN ehlanganiswe nge-biotechnology. I-PDRN yendabuko ikhishwa ngokuyinhloko ku-salmon, inqubo evinjelwa izindleko eziphezulu, ukuhlukahluka kwe-batch-to-batch, kanye nobumsulwa obunomkhawulo. Ngaphezu kwalokho, ukuthembela emithonjeni yemvelo kubangela ukukhathazeka kokusimama kwemvelo futhi kukhawulele ukuqina ukuze kuhlangatshezwane nesidingo esikhulayo semakethe. I-PromaCare®I-R-PDRN ibhekana nalezi zinselele ngokusebenzisa izinhlobo zebhaktheriya eziklanyelwe ukuphindaphinda izingcezwana ze-PDRN eziqondiwe, ivumela ukuhlanganiswa okulawulwayo kuyilapho kugcinwa ikhwalithi ekwazi ukukhiqizwa futhi kuncishiswe umthelela wemvelo.
Le ndlela yokuhlanganisa ivumela ukwakheka okunembile kokulandelana kokusebenza, okuholela emikhiqizweni ye-nucleic acid eklanyelwe imiphumela ethile ye-bioactive. Isisindo samangqamuzana nokuvumelana kwesakhiwo kwezingcezu kulawulwa ngokuqinile, okuthuthukisa kokubili ukufana nokungena kwesikhumba. Njengesithako esingenazilwane, i-PromaCare®I-R-PDN ihambisana namazinga okulawula omhlaba, yandisa ukwamukelwa kwemakethe ezindaweni ezibucayi.Inqubo yokukhiqiza ilandela izindinganiso eziqinile zekhwalithi, kusetshenziswa izindlela zokuvubela nezihlanza ezingaguquguquki eziletha ikhwalithi engaguquki, ukuhlanzeka okuphezulu, kanye nokunikezwa okuthembekile—kubhekwana nezindleko, uchungechunge lokuhlinzeka, kanye nezinselelo zemvelo zokukhishwa okuvamile.
I-Physicochemically, i-PromaCare®I-R-PDRN iyimpushana emhlophe, encibilika emanzini eyakhiwe i-DNA ene-RNA encane, etholakala ku-salmon PDRN ukulandelana, futhi ibonisa uhla lwe-pH lwe-5.0-9.0. Ihlukaniswa njengesithako sezinga lezimonyo esilungele ukusetshenziswa kuma-emulsions asezingeni eliphezulu, okhilimu, amabala wamehlo, imaski, nokunye ukwakheka kwesikhumba okuphambili. Ucwaningo lwe-in vitro lubonise ukuphepha nokusebenza ngempumelelo ekugxilweni kwe-100-200 μg / mL, ukusekela ukwanda kwamaseli kanye nomsebenzi wokulwa nokuvuvukala ngaphandle kwe-cytotoxicity.
Ucwaningo olusebenzayo luphinde lugqamise i-bioactivity ephakeme ye-PromaCare®I-R-PDN. Ithuthukisa kakhulu ukufuduka kwe-fibroblast, ifinyelela izinga lokusabalala kwe-131% emahoreni angama-41 uma kuqhathaniswa nezilawuli. Ngokuya nge-collagen synthesis, i-PromaCare®I-R-PDRN iphromotha i-collagen yohlobo lomuntu I-collagen izikhathi ezingu-1.5 bese ithayipha i-collagen III izikhathi ezingu-1.1 ngokuhlobene nezilawuli, idlula i-PDRN evamile etholakala ku-salmon. Ukwengeza, ivimbela kakhulu abalamuli abavuvukalayo njenge-TNF-α ne-IL-6. Uma kuhlanganiswe ne-sodium hyaluronate, i-PromaCare®I-R-PDN ikhombisa imiphumela ye-synergistic, ikhulisa ukufuduka kwamaseli, ikhombisa amandla aqinile okwakheka okusebenzisanayo ekunakekeleni isikhumba esivuselelayo nokulwa nokuguga.
Kafushane, i-PromaCare®I-R-PDRN ihlanganisa ukweqa kwezobuchwepheshe kusuka ekukhishweni okungokwesiko kuya ekuhlanganiseni kwe-biotechnological, ihlinzeka ngenye indlela ekwazi ukukhiqizwa kabusha, emsulwa kakhulu, nesimeme yokwenziwa kokunakekelwa kwesikhumba okusezingeni eliphezulu. I-bioactivity yayo ebonisiwe, iphrofayili yokuphepha, kanye nokuqina kwayo kuyibeka njengesithako esinamasu emikhiqizo yezimonyo eqondise ukulwa nokuguga, ukulungisa isikhumba, kanye nempilo yesikhumba iyonke, ehambisana ngokugcwele nesidingo esikhulayo sezithako zezimonyo ezisimeme neziqinisekiswa ngokwesayensi.
Chofoza lapha ukuze ufunde kabanzi mayelana nalo mkhiqizo.
Isikhathi sokuthumela: Aug-28-2025