RJMPDRN®I-REC imele intuthuko ephawulekayo ezithanjeni zezimonyo ezisekelwe ku-nucleic acid, enikeza i-saumoni ehlanganisiwe ye-PDRN ehlanganiswe nge-biotechnology. I-PDRN yendabuko ikhishwa ngokuyinhloko ku-salmon, inqubo evinjelwa izindleko eziphezulu, ukuhlukahluka kwe-batch-to-batch, kanye nobumsulwa obunomkhawulo. Ngaphezu kwalokho, ukuthembela emithonjeni yemvelo kubangela ukukhathazeka kokusimama kwemvelo futhi kukhawulele ukuqina ukuze kuhlangatshezwane nesidingo esikhulayo semakethe.
RJMPDRN®I-REC ibhekana nalezi zinselele ngokusebenzisa izinhlobo zamagciwane eziklanywe ngobunjiniyela ukuze iphindaphinde izingcezu ze-PDRN eziqondiwe, ivumela ukwenziwa okulawulwayo ngenkathi igcina ikhwalithi ephindaphindwayo futhi inciphisa umthelela wemvelo.
Le ndlela yokuhlanganisa ivumela ukwakheka okunembile kokulandelana kokusebenza, okuholela emikhiqizweni ye-nucleic acid eklanyelwe imiphumela ethile ye-bioactive. Isisindo samangqamuzana nokuvumelana kwesakhiwo kwezingcezu kulawulwa ngokuqinile, okuthuthukisa kokubili ukufana nokungena kwesikhumba. Njengesithako esingenazilwane, i-RJMPDRN®I-REC ihambisana namazinga okulawula omhlaba, yandisa ukwamukelwa kwemakethe ezindaweni ezibucayi. Inqubo yokukhiqiza ilandela izindinganiso eziqinile zekhwalithi, kusetshenziswa izindlela zokuvubela nezihlanza ezingaguquguquki eziletha ikhwalithi engaguquki, ukuhlanzeka okuphezulu, kanye nokunikezwa okuthembekile—kubhekwana nezindleko, uchungechunge lokuhlinzeka, kanye nezinselelo zemvelo zokukhishwa okuvamile.
I-Physicochemically, i-RJMPDRN®I-REC iyimpuphu emhlophe, encibilika emanzini eyakhiwe yi-DNA ene-RNA encane, etholakala ku-salmon PDRN sequences, futhi ibonisa ububanzi be-pH obungu-5.0–9.0. Ihlukaniswa njengesithako sezinga lobuhle esifanele ukusetshenziswa kuma-emulsion aphezulu, okhilimu, ama-eye patches, ama-masks, kanye nezinye izindlela zokunakekelwa kwesikhumba zekhwalithi ephezulu. Izifundo ze-in vitro zibonise ukuphepha kwayo kanye nokusebenza kwayo ekugxilweni okungu-100–200 μg/mL, okusekela ukwanda kwamaseli kanye nomsebenzi wokulwa nokuvuvukala ngaphandle kwe-cytotoxicity.
Ucwaningo olusebenzayo luphinde lugqamise i-bioactivity ephakeme ye-RJMPDRN®REC. Ithuthukisa kakhulu ukufuduka kwe-fibroblast, ifinyelela izinga lokusabalala kwe-131% emahoreni angama-41 uma kuqhathaniswa nezilawuli. Ngokuya nge-collagen synthesis, i-RJMPDRN®I-REC iphromotha i-collagen yohlobo lomuntu I izikhathi ezingu-1.5 bese ithayipha i-collagen III izikhathi ezingu-1.1 ngokuhlobene nezilawuli, idlula i-PDRN evamile etholakala ku-salmon. Ukwengeza, ivimbela kakhulu abalamuli abavuvukalayo njenge-TNF-α ne-IL-6. Uma kuhlanganiswe ne-sodium hyaluronate, , RJMPDRN®I-REC ikhombisa imiphumela yokusebenzisana, okwandisa ukufuduka kwamaseli, okubonisa amandla amakhulu okubambisana ekunakekelweni kwesikhumba okuvuselelayo nokulwa nokuguga.
Kafushane, i-RJMPDRN®I-REC imele intuthuko kwezobuchwepheshe kusukela ekukhishweni kwendabuko kuya ekuhlanganisweni kwe-biotechnology, ihlinzeka ngendlela ephindaphindwayo, emsulwa kakhulu, futhi eqhubekayo yokwenza izinto zokunakekelwa kwesikhumba ezisezingeni eliphezulu. Ukusebenza kwayo okubonakalayo kwe-bioactive, iphrofayili yokuphepha, kanye nokukhula kwayo kuyibeka njengesithako esibalulekile semikhiqizo yezimonyo ehlose ukulwa nokuguga, ukulungiswa kwesikhumba, kanye nempilo yesikhumba iyonke, okuhambisana ngokugcwele nesidingo esishintshashintshayo sezithako zezimonyo ezisimeme neziqinisekisiwe ngokwesayensi.
Chofoza lapha ukuze ufunde kabanzi mayelana nalo mkhiqizo.
Isikhathi sokuthumela: Aug-28-2025