RJMPDRN®I-REC imele intuthuko ephawulekayo ezithanjeni zezimonyo ezisekelwe ku-nucleic acid, enikeza i-saumoni ehlanganisiwe ye-PDRN ehlanganiswe nge-biotechnology. I-PDRN yendabuko ikhishwa ngokuyinhloko ku-salmon, inqubo evinjelwa izindleko eziphezulu, ukuhlukahluka kwe-batch-to-batch, kanye nobumsulwa obunomkhawulo. Ngaphezu kwalokho, ukuthembela emithonjeni yemvelo kubangela ukukhathazeka kokusimama kwemvelo futhi kukhawulele ukuqina ukuze kuhlangatshezwane nesidingo esikhulayo semakethe.
RJMPDRN®I-REC ibhekana nalezi zinselele ngokusebenzisa izinhlobo zebhaktheriya eziklanyelwe ukuphindaphinda izingcezwana ze-PDRN eziqondiwe, ivumela ukuhlanganiswa okulawulwayo kuyilapho igcina ikhwalithi ekwazi ukukhiqizwa futhi inciphisa umthelela wemvelo.
Le ndlela yokuhlanganisa ivumela ukwakheka okunembile kokulandelana kokusebenza, okuholela emikhiqizweni ye-nucleic acid eklanyelwe imiphumela ethile ye-bioactive. Isisindo samangqamuzana nokuvumelana kwesakhiwo kwezingcezu kulawulwa ngokuqinile, okuthuthukisa kokubili ukufana nokungena kwesikhumba. Njengesithako esingenazilwane, i-RJMPDRN®I-REC ihambisana namazinga okulawula omhlaba, yandisa ukwamukelwa kwemakethe ezindaweni ezibucayi. Inqubo yokukhiqiza ilandela izindinganiso eziqinile zekhwalithi, kusetshenziswa izindlela zokuvubela nezihlanza ezingaguquguquki eziletha ikhwalithi engaguquki, ukuhlanzeka okuphezulu, kanye nokunikezwa okuthembekile—kubhekwana nezindleko, uchungechunge lokuhlinzeka, kanye nezinselelo zemvelo zokukhishwa okuvamile.
I-Physicochemically, i-RJMPDRN®I-REC iyimpushana emhlophe, encibilika emanzini eyakhiwe i-DNA ene-RNA encane, etholakala ekulandeleni kwe-salmon PDRN, futhi ibonisa uhla lwe-pH lwe-5.0-9.0. Ihlukaniswa njengesithako sezinga lezimonyo esilungele ukusetshenziswa kuma-emulsions asezingeni eliphezulu, okhilimu, amabala wamehlo, imaski, nokunye ukwakheka kwesikhumba okuphambili. Ucwaningo lwe-in vitro lubonise ukuphepha nokusebenza ngempumelelo ekugxilweni kwe-100-200 μg / mL, ukusekela ukwanda kwamaseli kanye nomsebenzi wokulwa nokuvuvukala ngaphandle kwe-cytotoxicity.
Ucwaningo olusebenzayo luphinde lugqamise i-bioactivity ephakeme ye-RJMPDRN®REC. Ithuthukisa kakhulu ukufuduka kwe-fibroblast, ifinyelela izinga lokusabalala kwe-131% emahoreni angama-41 uma kuqhathaniswa nezilawuli. Ngokuya nge-collagen synthesis, i-RJMPDRN®I-REC iphromotha i-collagen yohlobo lomuntu I izikhathi ezingu-1.5 bese ithayipha i-collagen III izikhathi ezingu-1.1 ngokuhlobene nezilawuli, idlula i-PDRN evamile etholakala ku-salmon. Ukwengeza, ivimbela kakhulu abalamuli abavuvukalayo njenge-TNF-α ne-IL-6. Uma kuhlanganiswe ne-sodium hyaluronate, , RJMPDRN®I-REC ibonisa imiphumela ye-synergistic, ukwandisa ukufuduka kwamaseli, okubonisa amandla aqinile okwakhiwa okusebenzisanayo ekunakekeleni isikhumba esivuselelayo nesinqanda ukuguga.
Kafushane, i-RJMPDRN®I-REC ihlanganisa ukweqa kobuchwepheshe kusukela ekukhishweni okungokwesiko kuya ekuhlanganiseni kwe-biotechnological, ihlinzeka ngenye indlela ekwazi ukukhiqizwa kabusha, emsulwa kakhulu, nesimeme yokwenziwa kokunakekelwa kwesikhumba okusezingeni eliphezulu. I-bioactivity yayo ebonisiwe, iphrofayili yokuphepha, kanye nokuqina kwayo kuyibeka njengesithako esinamasu emikhiqizo yezimonyo eqondise ukulwa nokuguga, ukulungisa isikhumba, kanye nempilo yesikhumba iyonke, ehambisana ngokugcwele nesidingo esikhulayo sezithako zezimonyo ezisimeme neziqinisekiswa ngokwesayensi.
Chofoza lapha ukuze ufunde kabanzi mayelana nalo mkhiqizo.
Isikhathi sokuthumela: Aug-28-2025