| I gama le-brand: | I-Recombinant PDRN |
| Inombolo ye-CAS: | / |
| Igama le-INCI: | I-DNA yeSodium |
| Isicelo: | Ama-lotion amahle aphakathi kuya kwaphezulu, okhilimu, ama-patches amehlo, imaski, njll. |
| Iphakheji: | 50g |
| Ukubukeka: | Impuphu emhlophe |
| Izinga lomkhiqizo: | Izinga lobuhle |
| Ukuncibilika: | Incibilika emanzini |
| i-pH (1% isixazululo samanzi): | 5.0 -9.0 |
| Isikhathi sokuphelelwa yisikhathi | iminyaka engu-2 |
| Isitoreji: | Gcina endaweni epholile kude nokukhanya kwelanga endaweni yokushisa kwegumbi |
| Isilinganiso: | 0.01%-2.0% |
Isicelo
Isizinda se-R&D:
I-PDRN yendabuko ikhishwa kakhulu ezicutshini zamasende ze-salmon. Ngenxa yokwehlukahluka kobuchwepheshe phakathi kwabakhiqizi, le nqubo ayibizi nje kuphela futhi ayizinzile kodwa futhi ilwela ukuqinisekisa ubumsulwa bomkhiqizo kanye nokuvumelana kwe-batch-to-batch. Ngaphezu kwalokho, ukuthembela ngokweqile ezinsizeni zemvelo kubeka ingcindezi enkulu endaweni yemvelo futhi kwehluleka ukuhlangabezana nesidingo esikhulu semakethe yesikhathi esizayo.
Ukwenziwa kwe-PDRN etholakala ku-salmon ngendlela ye-biotechnological kuphumelela ukudlula imikhawulo yokukhishwa kwezinto eziphilayo. Le ndlela ayigcini nje ngokuthuthukisa ukusebenza kahle kokukhiqiza kodwa futhi iqeda ukuthembela ezinsizeni zezinto eziphilayo. Ibhekana nokuguquguquka kwekhwalithi okubangelwa ukungcola noma ukungcola ngesikhathi sokukhishwa, kufezwe ukukhuphuka kwe-quantum ekuhlanzekeni kwezingxenye, ukuhambisana kokusebenza kahle, kanye nokulawulwa kokukhiqiza, ngaleyo ndlela kuqinisekiswe ukukhiqizwa okuzinzile nokukhuliswayo.
Izinzuzo Zobuchwepheshe:
1. Uchungechunge Lokusebenza Oluklanywe Ngokunembile Oluyi-100%
Ifinyelela ukuphindaphindwa okunembile kochungechunge oluqondiwe, yakha imikhiqizo ye-nucleic acid eyenziwe ngokwezifiso "eklanywe kahle" ngempela.
2. Ukuvumelana Kwesisindo Sama-Molecular kanye Nokumiswa Kwesakhiwo
Ubude bezingcezu ezilawulwayo kanye nesakhiwo sokulandelana kuthuthukisa kakhulu ukulingana kwezingcezu zama-molecule kanye nokusebenza kwe-transdermal.
3. Izingxenye Ezingekho Ezivela Ezilwaneni, Ezihambisana Nemikhuba Yokulawula Yomhlaba Wonke
Kukhulisa ukwamukelwa kwemakethe ezindaweni ezibucayi zokusetshenziswa.
4. Amandla Okukhiqiza Omhlaba Wonke Azinzile Futhi Angakhula.
Ngaphandle kwemithombo yemvelo, ivumela ukusabalalisa okungenamkhawulo kanye nokutholakala okuzinzile komhlaba wonke ngezinqubo zokubilisa ezithuthukisiwe kanye nokuhlanza, ibhekana ngokuphelele nezinselele ezintathu ezinkulu ze-PDRN yendabuko: izindleko, uchungechunge lokuhlinzeka, kanye nokusimama kwemvelo.
Izinto zokusetshenziswa ze-Recombinant PDRN zihambisana kahle nezidingo zentuthuko eluhlaza kanye nentuthuko esimeme yemikhiqizo ephakathi kuya kwephezulu.
Idatha Yokusebenza Kahle Nokuphepha:
1. Kukhuthaza Ngokuphawulekayo Ukulungiswa Nokuvuselelwa:
Ukuhlolwa kwe-in vitro kubonisa ukuthi umkhiqizo uthuthukisa kakhulu ikhono lokufuduka kwamaseli, ubonisa ukusebenza kahle kakhulu ekukhuthazeni ukukhiqizwa kwe-collagen uma kuqhathaniswa ne-PDRN yendabuko, futhi uletha imiphumela evelele yokulwa nemibimbi kanye nokuqina.
2. Ukusebenza Okulwa Nokuvuvukala:
Ivimbela ngempumelelo ukukhishwa kwezinto ezibalulekile zokuvuvukala (isb., i-TNF-α, i-IL-6).
3. Amandla Ayingqayizivele Okubambisana:
Uma kuhlanganiswa ne-sodium hyaluronate (ukuhlushwa: 50 μg/mL ngayinye), izinga lokufuduka kwamaseli lingakhuphuka ngamaphesenti angama-93 zingakapheli amahora angama-24, okubonisa amandla amahle kakhulu okusetshenziswa okuhlanganisiwe.
4. Uhla Lokuhlushwa Okuphephile:
Izifundo ze-in vitro zibonisa ukuthi i-100-200 μg/mL iyibanga lokuhlushwa eliphephile nelisebenzayo emhlabeni wonke, lilinganisa kokubili imisebenzi yokukhulisa (umphumela ophezulu emahoreni angu-48-72) kanye nemisebenzi yokulwa nokuvuvukala.
5. Kuthuthukisa Ukukhiqizwa Kwe-Collagen:
I-Recombinant PDRN ibonise ukwanda okuphindwe ka-1.5 ekukhiqizweni kwe-collagen yohlobo I uma kuqhathaniswa neqembu lokulawula elingenalutho, kuyilapho ikhombisa nokuthuthukiswa okuphindwe ka-1.1 ekwakhiweni kwe-collagen yohlobo III.
