I-INCI efanayo, Indaba Ehlukile Yokunikezwa: Ukuqonda i-Recombinant PDRN

I-PDRN ithola ukunakwa okwandayo ekunakekelweni kwesikhumba, kodwa igama le-INCI lodwa alivezi ukuthi isithako sitholakala noma sikhiqizwa kanjani.

Ngaphakathi kwephothifoliyo ye-PDRN ye-Uniproma, i-PDRN etholakala ku-salmon kanye ne-recombinant ibizwa ngokuthi i-Sodium DNA. Naphezu kokwabelana ngegama elifanayo le-INCI, lezi zindlela ezimbili zihluka kakhulu endleleni yokukhiqiza, ukulawulwa kwekhwalithi kanye nokukhula kokunikezwa.

I-PDRN etholakala ku-salmon inikeza indawo yokuqala ebalulekile yesayensi ngenxa yomlando wayo osungulwe ekwelashweni kokuvuselela, ukusetshenziswa kobuhle kanye nokunakekelwa kwesikhumba. Ngokwakhela kulokhu kubhekisela, i-Uniproma yenze ukulandelana okubanzi kanye nokuqhathanisa imikhiqizo ye-PDRN neye-PN yezentengiselwano, ikhetha izingcezu zezakhi zofuzo ezingu-99 ezifanele zokuthuthukiswa okuqhubekayo kwe-recombinant.

Ngokungafani nokukhishwa okuvamile ezicutshini zezinto eziphilayo, i-PDRN ephinda isetshenziswe ilandela indlela yokukhiqiza elawulwayo:

Ukukhethwa kokulandelana kwenhloso → ukwakhiwa kwe-plasmid → ukubiliswa kwamagciwane → ukubanjwa komkhiqizo oqondiwe → ukuhlanzwa komfula

Ngemva kokubilisa, izinqubo zokuhlanza ezansi zenzelwe ukususa ama-metabolites okubilisa, amaprotheni e-host-cell kanye ne-DNA ye-host-cell, kanye ne-chromatography ye-ion-exchange enikeza isinyathelo esengeziwe sokuhlanza. Le nqubo elawulwayo isekela ubumsulwa, ukuhambisana kwe-batch kanye nokulandelela kobuchwepheshe.

Ukukhiqizwa okusekelwe ekuvuthweni kunciphisa nokuthembela ezinsizeni zebhayoloji zesizini futhi kunikeza indlela enwebekayo kusukela enanini lokuthuthukiswa kuya ekukhiqizweni kwezentengiselwano.

Ukusebenza kahle nakho kuhlolwe ngaphakathi emzimbeni. Ngemva kwezinsuku ezingu-28 zokusetshenziswa ku-0.1%, i-recombinant PDRN ibonise:

·Ukwehliswa kwe-TEWL ngo-17.37%

·Ukuncipha kwe-erythema ngo-12.40%

·Ukuthuthukiswa kokunwebeka kwesikhumba okungu-30.11%

·Ukwehla kwenani lama-wrinkle ngo-46.67%

Lokhu okutholakele kusekela amandla ayo okulungisa izithiyo, ukuthobisa, ukuqinisa kanye nokwakha imibimbi.

Kubakhiqizi bemikhiqizo kanye nemikhiqizo, ukuhlola i-PDRN kusho ukubheka ngale kwegama le-INCI ukuze uqonde uhlelo lokukhiqiza, izilawuli zekhwalithi kanye nemodeli yokuhlinzeka ngemuva kwesithako.

I-Uniproma inikeza imibhalo yobuchwepheshe, isiqondiso sokwakheka, ulwazi olusezingeni eliphezulu kanye nokusekelwa kokuhlinzekwa kwezentengiselwano kokuthuthukiswa kwe-PDRN ephinde yahlanganiswa.